Principal Scientist (Director), Anatomic Pathologist
Job Description
Job Description:
Translational Molecular Biomarkers is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our company’s Research Laboratories. Translational Molecular Biomarkers laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response.
The Molecular Pathology group within the Translational Molecular Biomarkers organization is seeking a highly motivated and experienced Anatomic Pathologist (MD) for the role of Principal Scientist (Director) to join our innovative team. This position will play a crucial role in the supporting the development, analytical validation, and testing of histopathology-based assays for clinical implementation and advancing digital pathology within our company’s clinical therapeutic pipeline.
ThePrincipal Scientist (Director)will have the following responsibilities:
Engage in providing thorough histopathological reviews and testing clinical samples, leveraging expertise in disease processes and pathways targeted by our company’s therapeutics.
Collaborate in the development and analytic validation of digital pathology algorithms.
Interface with scientists and physicians in early and late-stage clinical development to execute histopathology-based biomarker strategies in clinical trials.
Establish new histopathology-based assays in the laboratory as part of a team.
Provide subject matter of expert pathologist input to discussions in a highly matrixed environment, collaborating with internal and external stakeholders.
Position Qualifications:
Education Minimum Requirement:
Doctor of Medicine (MD or MD/PhD) with specialized training in Anatomic Pathology.
Required Experience and Skills:
Proficient in routine histopathology testing, immunohistochemistry (IHC), cytogenetics (in-situ hybridization) testing procedures, and applicable laboratory testing regulations.
Experience ensuring compliance of a clinical laboratory with regulatory standards.
Experience with the development and analytic validation of digital pathology algorithms.
Excellent oral and written skills with a proven record of scientific contributions to the scientific community.
Demonstrated ability to lead and manage projects in a fast-paced environment.
Ability to interact well with diverse groups and maintain strong working relationships with internal and external collaborators.
Eplinary teams.
Strong understanding of disease processes and pathways relevant to our company’s therapeutics.
Preferred Experience and Skills:
Experience working in the pharmaceutical industry.
Broad knowledge of the drug development process and translational medicine.
Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development.
Experience with multiplex tissue-based spatial profiling assays (i.e., multiplex immunofluorescence, multiplex chromogenic immunohistochemistry, imaging mass cytometry).
Familiarity with image acquisition platforms (i.e., Leica Aperio, Hamamatsu, Pannoramic).
Proficiency in commercial or open-source image analysis software packages (i.e., Visiopharm, HALO, QuPath).
Knowledge of using statistical software packages (i.e., Prism, SPSS).
Understanding of regulated clinical bioanalysis.
Required Skills:
Anatomic Pathology, Biomarker Development, Clinical Studies, Digital Pathology, Molecular Pathology
Preferred Skills:
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U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday – Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
The salary range for this role is
$250,800.00 – $394,800.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
VISA Sponsorship:
Travel Requirements:
Flexible Work Arrangements:
Hybrid
Shift:
Valid Driving License:
Hazardous Material(s):
Job Posting End Date:
11/7/2025
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